Menopause & Osteoporosis

Risk factors for developing osteoporosis are:

  • Ethnicity (particularly Caucasian subjects). This is due to lifestyle (diet rich in calcium, protein and low in vitamins, including vitamins D, B12 and K)
  • Age high
  • The female
  • Low body mass index
  • Family history of fractures of the femoral neck
  • Deficiencies in calcium and protein
  • Excessive consumption of tobacco, alcohol, coffee,
  • The vitamin D deficiency (lack of sunshine and vegetable consumption)
  • Physical inactivity, prolonged immobilization
  • Deficit in sex hormones

premature menopause induced or spontaneous, castration (both sexes) chemical or surgical No late puberty,

  • Certain hormonal diseases, hyperthyroidism, hyperparathyroidism, diabetes mellitus, hyperadrenocorticism (Cushing’s disease.)
  • Hyperandrogenism, Klinefelter syndrome, Turner syndrome
  • Metabolic diseases: hemochromatosis gene, isolated hypercalciuria, idiopathic or family
  • Inflammatory rheumatism: rheumatoid arthritis, ankylosing spondylitis,
  • Other chronic diseases: chronic renal failure, hepatocellular failure, cirrhosis, mastocytosis
  • Some treatments, especially corticosteroids prolonged GnRH analogues, aromatase inhibitors.

At the genetic level, mutations in several genes LPR5 and LPR6 (low-density lipoprotein receptor) appear to correlate with a slightly increased risk of osteoporosis

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