Immunotherapy : Treatment Alzhiemer
The cure for Alzheimer’s disease by a vaccine is feasible, according to studies conducted in animals. Unfortunately, studies in humans have been very disappointing for two reasons. The major side effects (death) were observed. Moreover, the immunotherapy did not prevent the development of Alzheimer’s disease. Also, these approaches are the research and no drug of this type is marketed today.
The idea is not new: in 1999, Dale Schenk, an American researcher, found in the journal Nature a method for getting rid of the disease in mice. By immunizing against peptide A beta transgenic mice that overexpress it comes to preventing the occurrence of deposits in young animals and to limit and even reduce their spread among older individuals.
A first trial of Phase 1 in humans leads to England has the following analysis: 80 patients tolerate well the vaccine and a quarter of them produce many antibodies. A second trial was discontinued due to serious adverse events (meningoencephalitis). The subsequent monitoring of patients who received the vaccine is more mixed: while intracerebral amyloid deposits are less significant, no effect on the intellectual deterioration has been proved
